HCID 67959747, compound → HCID 67959676, compound

Participants

Reaction Conditions

Reaction Steps

A glass microwave reaction vessel was charged with tert-butyl 1-(6-(5-(2,6-dimethoxypyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-4-ylcarbamate (141 mg, 0.229 mmol) in DCM (1 mL) and TFA (0.5 mL). The reaction mixture was stirred and heated in an Initiator microwave reactor (Personal Chemistry, Biotage AB, Inc., Uppsala, Sweden) at 85° C. for 20 min. The solvent was then removed and the residue was purified with RP-HPLC to give 1-(6-(5-(2,6-dimethoxypyrimidin-4-yl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-4-amine as a solid. MS (ESI, pos. ion) m/z: 433 (M+1).

Provenance & Evidence