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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1529317Generated: November 1, 2026

4-Toluenesulfonyl chloride → 5-(2-chloro-6-fluorophenyl)-3-iodo-1-tosyl-1H-indole

https://huagongshe.com/reaction/1529317

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Toluenesulfonyl chlorideHCID 7397—
Reactant5-(2-chloro-6-fluorophenyl)-3-iodo-1H-indoleHCID 67960105—
Product5-(2-chloro-6-fluorophenyl)-3-iodo-1-tosyl-1H-indoleHCID 6795976846.7%

Reaction Steps

This title compound was prepared analogously to compound 25d using 5-(2-chloro-6-fluorophenyl)-3-iodo-1H-indole (23 g, 0.07 mol) and tosyl chloride (17.7 g, 0.09 mol) to obtain the title compound (17.2 g, 46%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090593B2
Source datasetuspto-grants-2015_07
ORD IDord-6c2d01f145a34cf0a19bdf37fe7b4ba5
Source noteuspto-grants-2015_07