Methanol → 5-Bromo-3-(2-(methylsulfonyl)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Participants

Reaction Steps

To a RT slurry of 5-bromo-3-(2-(methylthio)pyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (0.855 g, 2.109 mmol) in MeOH (40 mL) was added oxone, monopersulfate compound (6.46 g, 10.51 mmol, Aldrich) and the reaction was stirred overnight. The reaction mixture was concentrated to ˜50% volume and diluted with water. The slurry was neutralized with 5 N NaOH and the solids were filtered, washed consecutively with water and MeOH, and dried in vacuo to give 795 mg of a light-yellow amorphous solid. m/z: 437.9, 439.0 [M+1].

Provenance & Evidence