Trifluoroacetic acid → HCID 67959924, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of tert-butyl 3-(6-(4-(tert-butoxycarbonylamino)piperidin-1-yl)pyrazin-2-yl)-5-carbamoyl-1H-indole-1-carboxylate (200 mg, 0.37 mmol) in chloroform was added TFA at 0° C. The reaction mixture was heated at 50° C. for 12 h. After removal of TFA the crude product was purified by preparative HPLC to obtain title compound (25 mg, 20%) as a brown solid. MS (ESI, pos. ion) m/z: 337.1 (M+1).

Provenance & Evidence