Potassium Carbonate → HCID 86709787, compound

Participants

Reaction Steps

A mixture of (4R)-tert-butyl 4-(6-(1-(tetrahydro-2H-pyran-2-yl)-5-(2-((trimethylsilyl)ethynyl)phenyl)-1H-indazol-3-yl)pyrazin-2-yloxy)-6-azaspiro[2.5]octane-6-carboxylate (110 mg, 0.162 mmol) and potassium carbonate (112 mg, 0.811 mmol) in MeOH (1623 μL) was stirred at RT for 2 h. The mixture was diluted with EtOAc (150 ml), added to a separatory funnel, and washed with water (2×100 ml) before the organic layer was separated, dried over Na2SO4, and concentrated to give (4R)-tert-butyl 4-(6-(5-(2-ethynylphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl)pyrazin-2-yloxy)-6-azaspiro[2.5]octane-6-carboxylate (80 mg, 0.132 mmol, 81% yield) as a yellowish oil. MS (ESI, pos. ion) m/z: 606.2 (M+1).

Provenance & Evidence