Potassium Phosphate, Tribasic → HCID 67959633, compound

Participants

Reaction Conditions

Reaction Steps

A glass microwave reaction vessel was charged with 5-(2-fluorophenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine (102 mg, 0.208 mmol) and 3-chloro-5-methoxypyridazine (30 mg, 0.208 mmol) in p-dioxane/H2O (4:1, 1.5 mL) followed by potassium phosphate (88 mg, 0.415 mmol) and bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(ii) (7.35 mg, 10.38 μmol). The reaction was stirred and heated in a Initiator microwave reactor (Personal Chemistry, Biotage AB, Inc., Upssala, Sweden) at 105° C. for 1 h. The mixture was diluted with DCM and washed with water. The organic layer was dried, filtered and concentrated. The residue was purified with silica gel chromatography (eluting with 10-35% EtOAc in Hex) to give 5-(2-fluorophenyl)-3-(5-methoxypyridazin-3-yl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine (16 mg, 0.034 mmol, 16.25% yield) as a brown solid. MS (ESI, pos. ion) m/z: 475.0 (M+1).

Provenance & Evidence