(S)-5-dibenzylamino-1-methylpiperidin-2-one → HCID 28064098, compound

HRID 1529505Notes

Reaction equation

HRID 1529505 reaction equation
C([N:8](CC1C=CC=CC=1)[C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 59708472(S)-5-dibenzylamino-1-methylpiperidin-2-one

Product 1

HCID 28064098HCID 28064098, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.450 g (S)-5-dibenzylamino-1-methylpiperidin-2-one are suspended in 25 ml of methanol and hydrogenated with 0.150 g Pd/C 10% at a pressure of 3 bar and a temperature of 60° C. After 16 hours the catalyst is removed by suction filtering and the filtrate is evaporated to dryness. 0.190g of the product are obtained as an oil.

Workup

  1. customa temperature of 60° C
  2. customAfter 16 hours the catalyst is removed by suction
  3. filtrationfiltering
  4. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-313936c5473a4914984ad5d48a13674e
Source dataset
uspto-grants-2015_07
Patent number
US09090626B2

Reaction notes

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