(R)-(R)-quinuclidin-3-yl 2-amino-2-phenylacetate bis hydrochloride → [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxy-ethyl]amino]methyl]benzoate formate salt

Participants

Role	Name	HCID	Charge
Reactant	(R)-(R)-quinuclidin-3-yl 2-amino-2-phenylacetate bis hydrochloride	HCID 86720688	—
Reactant	[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl]3-formyl-2-hydroxy-benzoate	HCID 86720699	—
Product	[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 2-hydroxy-3-[[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxy-ethyl]amino]methyl]benzoate formate salt	HCID 86720700	—

Reaction Steps

The title compound was synthesized from [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl] 3-formyl-2-hydroxy-benzoate and Intermediate 8 via the same method described for Example 1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09090606B2
Source dataset	uspto-grants-2015_07
ORD ID	ord-120cd0e0e23447288c294aa20355aa9f
Source note	uspto-grants-2015_07