Trifluoroacetic acid → HCID 66608477, compound

Participants

Reaction Steps

Trifluoroacetic acid (0.5 mL, 0.65 mmol) was added to a solution of 4,6-dihydro-2-(phenoxymethyl)-5H-pyrrolo[3,4-d]oxazole-5-carboxylic acid 1,1-dimethylethyl ester (0.075 g, 0.19 mmol) in DCM (0.5 mL). The mixture was stirred at room temperature for 15 minutes and diluted with a saturated solution of Na2CO3. The organic layer was separated, dried (Na2SO4), filtered and the solvents evaporated in vacuo to yield 5,6-dihydro-2-(phenoxymethyl)-4H-pyrrolo[3,4-d]oxazole (22 mg, 53% yield, 30% pure) as a clear oil that was used in the next step without further purification. C12H12N2O2LCMS: Rt 1.04, m/z 217 [M+H]+ (using method, LC-MS Method 6).

Provenance & Evidence