Sodium borohydride → HCID 66608179, compound

Participants

Reaction Steps

Sodium borohydride (0.035 g, 0.94 mmol) was added to a stirred suspension of 5-(2-fluorobenzoyl)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-carboxylic acid methyl ester (0.25 g, 0.78 mmol) in MeOH (5 mL). The mixture was stirred at room temperature for 3 hours, diluted with H2O and extracted with AcOEt. The organic layer was separated, dried (Na2SO4), filtered and the solvent evaporated in vacuo. The crude product was purified by preparative TLC (AcOEt in petroleum ether 50/50) to yield 5-(2-fluorobenzoyl)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-methanol (0.18 g, 79% yield).

Provenance & Evidence