HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-methyl-6-nitro-1H-indole → 3-Methyl-1h-indol-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-methyl-6-nitro-1H-indole | HCID 3358854 | — |
| Reactant | HCID 3807122 | HCID 3807122 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Methyl-1h-indol-6-amine | HCID 18916040 | 24% |
Reaction Steps
A mixture of 3-methyl-4-nitro-1H-indole and 3-methyl-6-nitro-1H-indole (3 g, 17 mol) and 10% Pd—C (0.5 g) in ethanol (30 mL) was stirred overnight under H2 (1 atm) at room temperature. Pd—C was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography to give 3-methyl-1H-indol-6-ylamine (B-7) (0.6 g, 24%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090619B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-149a9ac65bc84b3eb65ef20091e73dd5 |
| Source note | uspto-grants-2015_07 |