Sulfuryl chloride → Ethyl 2-chloro-2-(2-fluorobenzoyl)acetate

HRID 1530022Notes

Reaction equation

HRID 1530022 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].S(Cl)([Cl:19])(=O)=O>C(OCC)C>[Cl:19][CH:9]([C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 296342Ethyl 3-(2-fluorophenyl)-3-oxopropanoate

Product 1

HCID 18473854Ethyl 2-chloro-2-(2-fluorobenzoyl)acetateYield 97.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using ethyl 3-(2-fluorophenyl)-3-oxopropanoate (1.0 g, 4.75 mmol), sulfuryl chloride (771 mg, 5.7 mmol) and diethyl ether (50 mL) as starting materials and in the same manner as in Example 20(i), the title compound (1.13 g, 97%) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-81f28f1461f94dbeac3576ac29a42dd6
Source dataset
uspto-grants-2015_07
Patent number
US09090601B2

Reaction notes

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