Sulfuryl chloride → Ethyl 2-chloro-3-(2-methoxyphenyl)-3-oxopropanoate

HRID 1530024Notes

Reaction equation

HRID 1530024 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].S(Cl)([Cl:20])(=O)=O>C(OCC)C>[Cl:20][CH:10]([C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[O:2][CH3:1])=[O:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 2759695Ethyl (2-methoxybenzoyl)acetate

Product 1

HCID 54152211Ethyl 2-chloro-3-(2-methoxyphenyl)-3-oxopropanoateYield 97%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using ethyl 3-(2-methoxyphenyl)-3-oxopropanoate (1.7 g, 7.4 mmol), sulfuryl chloride (1.2 g, 8.9 mmol) and diethyl ether (100 mL) as starting materials and in the same manner as in Example 20(i), the title compound (1.8 g, 97%) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-10668ae1f10b46c3b442b3cb50945ccd
Source dataset
uspto-grants-2015_07
Patent number
US09090601B2

Reaction notes

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