Sulfuryl chloride → Ethyl 2-chloro-3-(2-chlorophenyl)-3-oxopropanoate

HRID 1530030Notes

Reaction equation

HRID 1530030 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].S(Cl)([Cl:19])(=O)=O>C(OCC)C>[Cl:19][CH:9]([C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 292405Ethyl (2-chlorobenzoyl)acetate

Product 1

HCID 13593390Ethyl 2-chloro-3-(2-chlorophenyl)-3-oxopropanoateYield 85%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using ethyl 3-(2-chlorophenyl)-3-oxopropanoate (1.0 g, 5.0 mmol), sulfuryl chloride (810 mg, 6.0 mmol) and diethyl ether (50 mL) as starting materials and in the same manner as in Example 20(i), the title compound (1.0 g, 85%) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-4f975e86d9bb4d329c0af769c2099f89
Source dataset
uspto-grants-2015_07
Patent number
US09090601B2

Reaction notes

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