Borane → 3-(4-Bromophenyl)propan-1-ol

Participants

Reaction Steps

30.0 g (0.128 mol) of 3-(4-bromophenyl)propionic acid are initially introduced in 300 ml of THF, and 257 ml (0.257 mol) of a 1 M solution of boron hydride in THF are added dropwise with ice cooling. The batch is left to stir overnight at room temp., carefully hydrolysed with cooling, and extracted three times with MTB ether. The combined org. phases are washed with sat. sodium chloride solution and dried over sodium sulfate. The solvent is removed in vacuo, and the residue is filtered through silica gel with MTB ether, giving 3-(4-bromophenyl)propan-1-ol, which is employed in the next step without further purification.

Provenance & Evidence