Nicotinic Acid → HCID 71001872, compound

Participants

Reaction Conditions

Reaction Steps

Nicotinic acid (75 g, 0.61 mmoles) and 20 g of xylene were charged to a reactor that is equipped with a sub-surface nitrogen flow, a Dean-Stark trap filled with 20 g of xylene, and a mechanical stirrer. 2-Ethylhexylamine (86.2 g, 0.67 moles) was added to this mixture dropwise. The mixture was heated to up to 210° C. and held until about 9 mL of water collected in the Dean-Stark trap. The mixture was then vacuum stripped to provide a dark residue that contained about 12.1% nitrogen and had infra-red bands at 3300, 1636.7, 1542.1, and 706 cm−1.

Provenance & Evidence