反应详情

温度

200 °C

2-Ethylhexyl alcohol (215.5 g, 1.65 mol) was charged to a 500 ml resin kettle and equipped with mechanical stir, a Dean-Stark trap and a thermocouple. The mixture was stirred at 300 rpm and nicotinic acid (61.5 g, 0.5 mol) was added in portions through a powder funnel. The mixture was heated to 200° C. with sub-surface nitrogen flow and held for 6 hours. The mixture was then cooled to 150° C. and vacuum was applied to −15 in Hg and held for 45 min. 22.9 g process oil was added and the mixture was then allowed to cool to room temperature under nitrogen atmosphere. The resulting mixture was then filtered twice through Celite Hyflow and Whatman #1 filter paper to yield desired product.

1. customequipped with mechanical stir
2. additionwas added in portions through a powder funnel
3. temperatureThe mixture was then cooled to 150° C.
4. waitheld for 45 min
5. addition22.9 g process oil was added
6. temperatureto cool to room temperature under nitrogen atmosphere
7. filtrationThe resulting mixture was then filtered twice through Celite Hyflow and Whatman #1
8. filtrationfilter paper