反应详情

温度

80 °C

To a stirred solution of the crude methyl 5-bromo-3-(cyclopentylamino)-2-methylbenzoate (0.7 g, 2.25 mmol) in acetonitrile (15 mL), cesium carbonate (1.47 g, 4.50 mmol) and methyl iodide (1.6 g, 11.26 mmol) were added; resulting reaction mass was heated at 80° C. for 7 h. On completion, reaction mass was cooled to room temperature and filtered, residue was washed with ethyl acetate and filtrate was concentrated and then purified by column chromatography to afford the desired compound (0.6 g, 82%).

1. customresulting
2. customreaction mass
3. customOn completion, reaction mass
4. temperaturewas cooled to room temperature
5. filtrationfiltered
6. washresidue was washed with ethyl acetate and filtrate
7. concentrationwas concentrated
8. custompurified by column chromatography