Cesium carbonate → HCID 68312961, compound

Participants

Reaction Steps

A mixture of 2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-ol from Example 4 (30 mg, 0.0922 mmol), Cs2CO3 (75 mg, 0.23 mmol) and 2-bromo-2-methylpropionic acid methyl ester (36 uL, 0.277 mmol) in CH3CN (2 mL) was heated at reflux temperature for 2 h. After cooling to RT, the mixture was partitioned between EtOAc and water. The aqueous layer was further extracted with EtOAc and the combined organic layers were washed with brine, then dried (Na2SO4) and concentrated in vacuo. The resulting residue was purified by column chromatography (Si-PCC, gradient 2-8% MeOH in DCM) affording 2-[2-(2-Isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylpropionic acid methyl ester as a colorless gum (40 mg, quantitative). LCMS: RT 3.25 min [M+H]+ 426.1

Provenance & Evidence