Sodium Hydroxide → HCID 68312906, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylpropionic acid methyl ester (39.2 mg, 0.0922 mmol) in MeOH (1.5 mL) was added 1M NaOH (0.46 mL) and the mixture was heated at 100° C. for 1 h using microwave irradiation. After cooling to RT, the organic solvent was removed in vacuo and the pH of the resulting mixture was adjusted to 8 by addition of 1M HCl. The mixture was then subjected to column chromatography (C18, gradient 25-40% MeOH in H2O followed by C18, gradient 1-20% MeOH in H2O) affording 2-[2-(2-Isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylpropionic acid (38 mg, quantitative). LCMS: RT 2.82 min [M+H]+ 412.0

Provenance & Evidence