HCID 68313002, compound → HCID 68312697, compound

Participants

Reaction Steps

To a solution of 4-benzyloxy-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutan-1-ol (29 mg, 0.0568 mmol) in IMS (5 mL) was added 10% Pd/C (5 mg). The reaction mixture was stirred at RT under a hydrogen atmosphere for 4 h. The suspension was then filtered through a pad of Celite® and the filtrate was concentrated in vacuo. To a solution of the residue thus obtained in IMS (5 mL) was added Pd(OH)2/C (10 mg) and the reaction mixture was stirred at RT under a hydrogen atmosphere for 18 h. The suspension was then filtered through a pad of Celite® and the filtrate was concentrated in vacuo. The resulting residue was purified by column chromatography (Si-PCC, gradient 2-10% MeOH in DCM) affording 2-[2-(2-Isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-methylbutane-1,4-diol as a colorless gum (14 mg, 56%). LCMS: RT 2.39 min [M+H]+ 428.3

Provenance & Evidence