2-(Pyrrolidin-1-ylmethyl)pyrrolidine → HCID 66558240, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 12-chloro-4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6,13-triazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaene from Example 135 (150 mg, 0.454 mmol), TEA (0.500 mL), and 1,2′-methylenedipyrrolidine (420 mg, 2.73 mmol) in NMP (0.500 mL) was stirred at 150° C. for 24 hr under nitrogen atmosphere. The resultant mixture was purified by reverse phase combiflash eluting with 0-50% gradient of CH3CN in 0.5% NH4HCO3 to afford 105 (81 mg, 40% yield) as white solid. LCMS (ESI): RT=4.54 min, m/z: 449.3 [M+H+]. 1H-NMR (500 MHz, DMSO-d6): δ 9.09 (s, 1H), 7.89 (s, 1H), 7.83 (s, 1H), 5.98-5.93 (m, 2H), 4.52-4.47 (m, 4H), 4.14 (s, 1H), 3.47 (s, 1H), 3.27 (s, 1H), 2.58-2.56 (m, 2H), 2.50-2.46 (m, 4H), 2.06-1.93 (m, 2H), 1.92-1.87 (m, 2H), 1.70-1.67 (m, 4H), 1.48 (s, 6H)

Provenance & Evidence