Aluminium lithium hydride → HCID 68313089, compound

Participants

Reaction Steps

To a solution of methyl 4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaene-13-carboxylate (1.70 g, 4.82 mmol) in THF (150 mL) was added LiAlH4 (732 mg, 19.3 mmol). The reaction mixture was heated to reflux for 2 hours. After cooling down, the reaction was quenched with a piece of ice cube at 0° C. The solid was filtered off and washed with ethyl acetate (3×30 mL). The combined filtrate was concentrate to give the crude product, which was purified by column chromatography on silica gel eluting with a 50% gradient of EtOAc in petroleum ether to afford {4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaen-13-yl}methanol (1.30 g, 83% yield) as a pale yellow solid. LCMS (ESI) m/z: 326.2 [M+H+].

Provenance & Evidence