1-Methylpiperazine → HCID 66558672, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-{4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaen-13-yl}ethyl methanesulfonate (246 mg, 0.590 mmol) in 1-methylpiperazine (25 mL) was heated at 90° C. for 16 h. The solvent was removed and the residue was purified by Combi-flash eluting with a 5-95% gradient of CH3CN in 0.3% NH4HCO3 to give 146. Separation of the enantiomers and further purification by chiral HPLC (AY-H column, 5% EtOH isocratic) gave: 44.3 mg of one enantiomer and 40.0 mg of the other (34% total yield).

Provenance & Evidence