Aluminium lithium hydride → HCID 68312910, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-{4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaen-13-yl}ethan-1-one (500 mg, 1.48 mmol) in THF (50 mL) was added LiAlH4 (0.282 g, 7.37 mmol). The mixture was heated at 60° C. for 1 h. After cooling to room temperature, the reaction was quenched with a piece of ice cube. The solid was filtered off and washed with ethyl acetate (3×10 mL). The combined filtrate was concentrated to give the crude product, which was purified by silica gel chromatography using 2% MeOH in DCM as eluant to give the desired product (420 mg, 83% yield) as a white solid. LCMS m/z [M+H]+ 340.3

Provenance & Evidence