2-(4-Piperidyl)-2-propanol → HCID 68313109, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-{4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaen-13-yl}ethyl methanesulfonate from Example 146 (123 mg, 0.295 mmol) in dioxane (15 mL) was added 2-(piperidin-4-yl)propan-2-ol (422 mg, 2.95 mmol). The mixture was heated at 90° C. overnight. The solvent was removed and the residue was purified by Combi-flash eluting with a 5-95% gradient of CH3CN in 0.3% NH4HCO3 to give 152. The enantiomers were separated by chiral SFC (OD-H column, 15% EtOH isocratic) to give: 17.6 mg of one enantiomer and 13.0 mg of the other (22% total yield)

Provenance & Evidence