反应详情

温度

110 °C

A mixture of 13-bromo-4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaene (200 mg, 0.540 mmol), 1-methyl-4-(pyrrolidin-2-yl)piperidine (108 mg, 0.640 mmol), Pd(PtBu3)2 (7 mg, 0.015 mmol), NaOtBu (155 mg, 1.62 mmol) in toluene (2 ml) in a seal tube was degassed with N2 for three times. The resulting mixture was stirred at 110° C. for 1 h. The solid was filtered off through Celite. The filtrate was concentrated to give the crude product, which was purified by prep-HPLC (Gilson GX 281, Shim-pack PRC-ODS 250 mm×20 mm×2, gradient: CH3CN/10 mm/L NH4HCO3, 17 min) to afford 161. The (R) and (S) enantiomers were further purified and separated by chiral HPLC (AD column, 30% EtOH (0.1% DEA) in n-Hexane isocratic) to give 6 mg of one enantiomer and 11 mg of the other (5% total yield)

1. customwas degassed with N2 for three times
2. filtrationThe solid was filtered off through Celite
3. concentrationThe filtrate was concentrated
4. customto give the crude product, which
5. customwas purified by prep-HPLC (Gilson GX 281, Shim-pack PRC-ODS 250 mm×20 mm×2, gradient: CH3CN/10 mm/L NH4HCO3, 17 min)