Potassium Carbonate → HCID 68312908, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-{4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaen-13-yl}ethylmethanesulfonate (0.19 mmol, 80 mg) in CH3CN (10 mL) was added K2CO3 (0.72 mmol, 106 mg) and azetidin-3-ol (0.38 mmol, 28 mg), the mixture was stirred at 80° C. for 16 h. After concentration, the residue was purified by reverse phase Combiflash eluting with a 0-50% gradient of CH3CN in 0.3% NH4HCO3 to give 1-(1-{4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaen-13-yl}ethyl)azetidin-3-ol (70 mg, 92% yield). LCMS (ESI) m/z: 395.1 [M+H+]

Provenance & Evidence