2-Iodobenzoic acid → 12-methyl-4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaene-13-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

To a solution of {12-methyl-4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaen-13-yl}methanol (92 mg, 0.271 mmol) in EtOAc (10 mL) was added 2-iodobenzoic acid (304 mg, 1.086 mmol). The mixture was heated at 80° C. overnight. The solid was filtered, the filtrate was concentrated and purified by silica gel chromatography eluting with EtOAc/petroleum ether (1:1) to give 12-methyl-4-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaene-13-carbaldehyde (65 mg, 71% yield) as a yellow solid. LCMS (ESI) m/z: 338.1 [M+H+].

Provenance & Evidence