Dimethylformamide dimethyl acetal → Tert-butyl 3-(3-(dimethylamino)acryloyl)pyrrolidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 3-acetylpyrrolidine-1-carboxylate (3.6 g, 16 mmol), DMF (10 mL), and DMF-DMA (20 mL) was stirred at 140° C. for 16 h. The resultant mixture was extracted with ethyl acetate, washed with brine, dried over MgSO4, filtered, and evaporated to afford tert-butyl 3-((E)-3-(dimethylamino)acryloyl)pyrro-lidine-1-carboxylate (4.44 g, 97% yield) as brown oil. LCMS (ESI) m/z: 213.3 [M-56+H+].

Provenance & Evidence