HCID 88932544, compound → HCID 86671474, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (E)-tert-butyl 2-(2,2,2-trifluoroethylidene)hydrazinecarboxylate (4.00 g, 18.9 mmol) and 20% Pd/C (2.00 g) in MeOH (20.0 mL) was stirred under H2 atmosphere at 25° C. for 16 h. The solid was filtered off and the filtrate was evaporated to give the crude product, which was purified by silica gel chromatography eluting with EtOAc/petroleum ether (1:100) to afford tert-butyl 2-(2,2,2-trifluoroethyl)hydrazinecarboxylate (1.32 g, 33% yield) as pale yellow oil. LCMS (ESI) m/z: 159.3 [M-56+H+].

Provenance & Evidence