Hydrogen chloride-ethyl acetate → 4-Hydrazinyl-1-methylpiperidine hydrochloride

HRID 1530650Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1530650
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([NH:8][NH:9]C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:17].CCOC(C)=O>>[ClH:17].[NH:8]([CH:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1)[NH2:9]

Komponenten

3

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 68313226Tert-butyl 2-(1-methylpiperidin-4-yl)hydrazinecarboxylate

Produkt 1

HCID 683128814-Hydrazinyl-1-methylpiperidine hydrochlorideAusbeute 100 %

Versuchsvorschrift

A mixture of tert-butyl 2-(1-methylpiperidin-4-yl)hydrazinecarboxylate (350 mg, 1.53 mmol) in sat. HCl/EtOAc solution (20 mL) was stirred at room temperature overnight. The solvent was removed under reduce pressure to afford 4-hydrazinyl-1-methylpiperidine hydrochloride (253 mg, 100% yield), which was used in the next step without further purification. LCMS (ESI) m/z: 130.3 [M+H+].

Aufarbeitung

  1. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-8b4573ab3b3642ba945052687ae2dd39
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09090628B2

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