Hydrogen chloride-ethyl acetate → 1-Tert-butyl-4-hydrazinylpiperidine hydrochloride

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Reaction Steps

A mixture of tert-butyl 2-(1-tert-butylpiperidin-4-yl)hydrazinecarboxylate (350 mg, 1.29 mmol) in sat. HCl/EtOAc solution (20 mL) was stirred at room temperature overnight. The solvent was removed under reduce pressure to afford 1-tert-butyl-4-hydrazinylpiperidine hydrochloride (268 mg, 100% yield), which was used in the next step without further purification. LCMS (ESI) m/z: 172.3 [M+H+].

Provenance & Evidence