1,4-Dioxane hydrochloride → HCID 68312924, compound

HRID 1530662Notes

Reaction equation

HRID 1530662 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH:10]2[CH2:14][CH2:13][CH2:12][N:11]2C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[ClH:22].O1CCOCC1>>[ClH:22].[CH:1]([N:4]1[CH2:5][CH2:6][CH:7]([CH:10]2[CH2:14][CH2:13][CH2:12][NH:11]2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68313045HCID 68313045, compound

Product 1

HCID 68312924HCID 68312924, compoundYield 100%

Procedure

A solution of tert-butyl 2-(1-isopropylpiperidin-4-yl)pyrrolidine-1-carboxylate (302 mg, 1.02 mmol) in 4N HCl/dioxane (5 mL) was stirred at room temperature for 8 h. Removal of the solvent gave the desired product (232 mg, 100% yield) as a yellow solid. LCMS m/z [M+H]+ 197.2

Workup

  1. customRemoval of the solvent

Sources & evidence

ORD record
ord-e945be31165349969a8e998b4a1f2ad2
Source dataset
uspto-grants-2015_07
Patent number
US09090628B2

Reaction notes

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