p-Toluenesulfonic acid → HCID 68312923, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 12-(1-ethoxyethenyl)-4-[1-(2-methoxypropyl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaene (190 mg, 0.480 mmol) and p-toluenesulfonic acid (11 mg, 0.060 mmol) in acetone (10 mL) was stirred at 60° C. for 75 min. The solid was filtered off and the filtrate was concentrated. The residue was purified by reverse phase Combiflash eluting with a 0-40% gradient of CH3CN in 0.3% NH4HCO3 to afford 1-{4-[1-(2-methoxypropyl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaen-12-yl}ethan-1-one (160 mg, 91% yield). LCMS (ESI) m/z: 368.1 [M+H+]

Provenance & Evidence