Triethylamine → HCID 86671479, compound

Participants

Reaction Steps

To a solution of 2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-2-phenylpropane-1,3-diol (115 mg, 0.242 mmol) and Et3N (101 μL, 0.725 mmol) in DCM (15 mL) cooled at 0° C. was added methanesulfonyl chloride (47 μL, 0.605 mmol) and stirring at RT was continued for 1.5 h. The mixture was diluted with DCM, washed with a saturated solution of NaHCO3, followed by water, then dried (Na2SO4) and concentrated in vacuo The resulting residue was purified by column chromatography (Si-PCC, gradient 2-8% MeOH in DCM) affording the title compound (124.5 mg, 81%) as a colourless gum. LCMS (Method J): RT 3.26 min [M+H]+ 632

Provenance & Evidence