Boron tribromide → 3-Fluoro-4,5-dihydroxybenzaldehyde

関与物質

反応手順

To a solution of 3-fluoro-4-hydroxy-5-(methyloxy)benzaldehyde (5.0 g, 29.4 mmol) in dichloromethane (80 ml) at 0° C. was added boron tribromide (43 ml, 1M solution in dichloromethane) dropwise and then the reaction was allowed to stir for 1 h at rt before the solvent was removed under reduced pressure and the residue acidified with aqueous HCl (1M). The resultant solid was filtered, washed with water and dried in vacuo to give the desired compound (0.66 g, 14%).

情報源と証拠