反应详情

To a stirred suspension of NaBH4 (638 mg, 16.8 mmol) in MeOH (15 mL), was added a solution of 1-{12-fluoro-4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaen-13-yl}ethan-1-one (1.55 g, 4.20 mmol) in MeOH (15 mL) at 0° C. under a nitrogen atmosphere. After the addition was completed, the cooling bath was removed and the mixture was stirred at room temperature for 1 h. After removal of the solvent, the residue was purified by silica gel chromatography using 5% dichloromethane in methanol as eluant to give the title compound (1.5 g, 96% yield) as a white solid. LCMS m/z [M+H]+ 372.1

1. additionAfter the addition
2. customthe cooling bath was removed
3. customAfter removal of the solvent
4. customthe residue was purified by silica gel chromatography