Triethylamine → HCID 86671482, compound

Participants

Reaction Steps

To a solution of 2-isobutyl-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]-propane-1,3-diol (88.6 mg, 0.194 mmol) and Et3N (81.1 μL, 0.582 mmol) in DCM (10 mL) cooled at 0° C. was added methanesulfonyl chloride (37.9 μL, 0.485 mmol) and stirring at RT was continued for 1.5 h. The mixture was diluted with DCM, washed with a saturated solution of NaHCO3, followed by water, then dried (Na2SO4) and concentrated in vacuo affording the title compound as a colourless gum (quantitative). LCMS (Method B): RT 3.46 min [M+H]+ 612.

Provenance & Evidence