Lithium Chloride → 13-(1-Ethoxyethenyl)-4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6,12-triazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaene

HRID 1530714Notes

Reaction equation

HRID 1530714 reaction equation
Cl[C:2]1[CH:15]=[C:14]2[C:5]([O:6][CH2:7][CH2:8][N:9]3[C:13]2=[N:12][C:11]([C:16]2[N:20]([CH:21]([CH3:23])[CH3:22])[N:19]=[C:18]([CH3:24])[N:17]=2)=[CH:10]3)=[CH:4][N:3]=1.C([Sn](CCCC)(CCCC)[C:30]([O:32][CH2:33][CH3:34])=[CH2:31])CCC.[Li+].[Cl-].[F-].[K+]>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH2:33]([O:32][C:30]([C:2]1[CH:15]=[C:14]2[C:5]([O:6][CH2:7][CH2:8][N:9]3[C:13]2=[N:12][C:11]([C:16]2[N:20]([CH:21]([CH3:23])[CH3:22])[N:19]=[C:18]([CH3:24])[N:17]=2)=[CH:10]3)=[CH:4][N:3]=1)=[CH2:31])[CH3:34]

Participants

7

Reactant 4

HCID 433294Lithium ChlorideHCID 522689Potassium FluorideHCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 8667148313-Chloro-4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6,12-triazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaene

Product 1

HCID 6831289413-(1-Ethoxyethenyl)-4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6,12-triazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaeneYield 51%

Reagents, catalysts & solvents 2

HCID 178418397HCID 178418397, compoundCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 13-chloro-4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6,12-triazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaene (1.60 g, 4.64 mmol), tributyl(1-ethoxyvinyl)stannane (1.70 g, 4.71 mmol), LiCl (585 mg, 13.9 mmol), and Pd(PPh3)4 (537 mg, 0.460 mmol) in THF (30 mL) in a sealed tube was stirred at 80° C. for 48 hrs under N2 atmosphere. After being cooled to room temperature, aq. KF (2.0 M, 50 mL) was added. The resulting mixture was stirred at room temperature for 1 h and then filtered. The filtrate was extracted with ethyl acetate (5×50 mL). The combined organic layers were washed brine and dried over MgSO4. Removal of the solvent gave the desired product (900 mg, 51% yield) as a yellow solid. 1H NMR (500 MHz, DMSO-d6) δ 8.63 (s, 1H), 8.35 (s, 1H), 8.04 (s, 1H), 5.90 (m, 1H), 5.30 (s, 1H), 4.64-4.60 (m, 4H), 4.39 (s, 1H), 3.95-3.94 (m, 2H), 2.27 (s, 3H), 1.51-1.48 (m, 6H), 1.42-1.39 (m, 3H). LCMS m/z [M+H]+ 381.3

Workup

  1. temperatureAfter being cooled to room temperature
  2. stirringThe resulting mixture was stirred at room temperature for 1 h
  3. filtrationfiltered
  4. extractionThe filtrate was extracted with ethyl acetate (5×50 mL)
  5. washThe combined organic layers were washed brine
  6. dry with materialdried over MgSO4
  7. customRemoval of the solvent

Sources & evidence

ORD record
ord-a76673c46d4945158ca753c6f22a0983
Source dataset
uspto-grants-2015_07
Patent number
US09090628B2

Reaction notes

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