1-Tert-butylpiperazine → HCID 68313151, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-{4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6,12-triazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaen-13-yl}ethyl methanesulfonate (240 mg) and 1-tert-butylpiperazine (281 mg, 1.97 mmol) in dioxane (5.00 mL) was stirred at 100° C. for 16 hrs under N2 atmosphere. After removal of the solvents, the residue was purified with reverse phase Combi-flash eluting with a 20-28% gradient of CH3CN in 0.3% NH4HCO3 to afford the desired product. The isolated solid was further separated by chiral SFC (AD-H column, EtOH (0.1% DEA) isocratic) to give the two enantiomers 303 and 305.

Provenance & Evidence