HCID 86671485, compound → HCID 68312943, compound

Participants

Reaction Steps

A solution of (R)-3-(1-allylamino-3-methanesulfonyloxypropyl)piperidine-1-carboxylic acid benzyl ester (326 mg, 0.794 mmol) in CH3CN (12 mL) was heated at 100° C. for 1 h using microwave irradiation. After cooling to RT, the reaction mixture was concentrated in vacuo. The residue was partitioned between 2M sodium carbonate and EtOAc. The aqueous phase was extracted with EtOAc. The combined organic phases were washed with brine, then dried (Na2SO4) and concentrated in vacuo. The resulting residue was purified by column chromatography (Si-PCC, gradient 2-5% 2M NH3/MeOH in DCM) affording the title compound (0.2127 g, 85%, 2 steps) as a colourless gum. LCMS (Method B): RT 2.03 min [M+H]+ 315.

Provenance & Evidence