p-Toluenesulfonic acid → HCID 68313061, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 13-(1-ethoxyethenyl)-12-methoxy-4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,4,10,12-pentaene (2.00 g) and 4-methylbenzenesulfonic acid (438 mg, 2.54 mmol) in acetone (20.0 mL) was stirred at 60° C. for 75 min. After removal of the solvent, the residue was purified by silica gel chromatography using 1-10% MeOH in DCM as eluant to afford the desired product (1.14 g, 80% yield for two steps). LCMS m/z [M+H]+ 382.3

Provenance & Evidence