HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1530755Generated: November 5, 2026
Acetic Anhydride → 4-Acetoxy-2-fluorobenzoic acid
https://huagongshe.com/reaction/1530755
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Fluoro-4-hydroxybenzoic Acid | HCID 2783398 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Acetoxy-2-fluorobenzoic acid | HCID 22721416 | — |
Reaction Steps
4.3 Grams of 4-hydroxy-2-fluorobenzoic acid and 8.4 g of acetic anhydride were placed in a two-necked flask and mixed. While the mixture was cooled with water, 5 drops of sulfuric acid were added. After heat generation ended, the mixture was heated at 80° C. for 30 minutes. Then, the reaction mixture was poured into cold water, and a precipitated crystal was recovered by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06197216B1 |
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| Source dataset | uspto-grants-2001_03 |
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| ORD ID | ord-b4b6f420b137465c865a874a1d809e54 |
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| Source note | uspto-grants-2001_03 |
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