HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1530773Generated: November 4, 2026
Acetic Anhydride → 4-Acetoxy-2-fluorobenzoic acid
https://huagongshe.com/reaction/1530773
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Fluoro-4-hydroxybenzoic Acid | HCID 2783398 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Acetoxy-2-fluorobenzoic acid | HCID 22721416 | — |
Reaction Steps
4.3 Grams of 4-hydroxy-2-fluorobenzoic acid and 8.4 g of acetic anhydride were placed in a two-necked flask and mixed. While the mixture was cooled with water, 5 drops of sulfuric acid were added. After heat generation ended, the mixture was heated at 80° C. for 30 minutes. Thereafter, the reaction mixture was poured into cold water, and a precipitated crystal was recovered by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06197389B1 |
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| Source dataset | uspto-grants-2001_03 |
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| ORD ID | ord-237d0c17f5094017b823a4ae8834afde |
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| Source note | uspto-grants-2001_03 |
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