Isonicotinic Acid → Pyridine-4-carbonyl chloride

Participants

Reaction Conditions

Reaction Steps

Isonicotinic acid (1.27 g, 10.36 mMole) was added to thionyl chloride (30 mL) and the mixture heated to 70° C. After 1 hour the solution was cooled, concentrated under reduced pressure and co-evaporated with ethyl acetate (2×30 mL). The residue was used as such in the following step.

Provenance & Evidence