反应详情

Then, 3.5 g (9.7 mmol) of 2-[2-fluoro-4-chloro-5-isopropoxyphenyl]-4-methyl-5-trifluoromethylpyridazin-3-one was dissolved in about 10 ml of concentrated sulfuric acid under ice cooling, and the solution was warmed to room temperature. After 10 minutes, about 100 ml of water was added to the reaction mixture. The precipitated crystals were collected by filtration and washed twice with 20 ml of water and then once with 10 ml of hexane. The resulting crystals were recrystallized from isopropanol to give 3.2 g (9.9 mmol) of 2-[2-fluoro-4-chloro-5-hydroxyphenyl]-4-methyl-5-trifluoromethylpyridazin-3-one.

1. filtrationThe precipitated crystals were collected by filtration
2. washwashed twice with 20 ml of water
3. customThe resulting crystals were recrystallized from isopropanol