HCID 11052309, compound → HCID 21252677, compound

HRID 1530802Notes

Reaction equation

HRID 1530802 reaction equation
[H][H].[F:3][C:4]([F:15])=[C:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)[CH3:6]>C(O)(=O)C.[Pd]>[F:3][CH:4]([F:15])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)[CH3:6]

Participants

5

Reactant 2

HCID 11052309HCID 11052309, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 21252677HCID 21252677, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

At 50° C. and 1 atm hydrogen pressure, 24.2 g of 1-(2,2-difluoro-1-methylvinyl)-4-methoxybenzene in 300 ml of glacial acetic acid were hydrogenated using palladium on carbon as catalyst until no further hydrogen uptake was visible. The catalyst was filtered off and the reaction solution was concentrated, to give the title product as a colourless oil which was reacted further without any purification.

Workup

  1. customAt 50° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe reaction solution was concentrated

Sources & evidence

ORD record
ord-2454c17961674686bcc7db8806f1cd8d
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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