Ammonium Chloride → 1,1,1-Trifluoro-2-(4-methoxyphenyl)propan-2-ol

HRID 1530806Notes

Reaction equation

HRID 1530806 reaction equation
[CH3:1][Mg]Cl.[CH3:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:17])[C:13]([F:16])([F:15])[F:14])=[CH:8][CH:7]=1.[Cl-].[NH4+]>CCOCC>[F:16][C:13]([F:15])([F:14])[C:12]([C:9]1[CH:10]=[CH:11][C:6]([O:5][CH3:4])=[CH:7][CH:8]=1)([OH:17])[CH3:1]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 1365552,2,2-Trifluoro-4'-methoxyacetophenoneHCID 178418332HCID 178418332, compound

Product 1

HCID 108677871,1,1-Trifluoro-2-(4-methoxyphenyl)propan-2-ol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

At −15° C., 18 ml of a 3 M solution of methylmagnesium chloride in ether were added dropwise to a solution of 5.8 g of 4′-methoxy-2,2,2-trifluoroacetophenone in 35 ml of ether, and the mixture was stirred at room temperature for 5 h. The reaction solution was hydrolysed with aqueous ammonium chloride and extracted with ether. The extract was dried and to give the title product as a colourless oil, which was reacted further without any purification.

Workup

  1. extractionextracted with ether
  2. customThe extract was dried

Sources & evidence

ORD record
ord-857351343a3c4696a3504a2f117127d1
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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