HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol → 4-(1-Hydroxy-2,2,2-trifluoroethyl)cyclohexanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol | HCID 11286977 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(1-Hydroxy-2,2,2-trifluoroethyl)cyclohexanol | HCID 21252659 | — |
Reaction Steps
At 50° C. and a hydrogen pressure of 150 bar, 44.1 g of 4-(1-hydroxy-2,2,2-trifluoroethyl)phenol were hydrogenated in the presence of 3 g of rhodium (5% on carbon) in 500 ml of isopropanol. The catalyst was filtered off and the mixture was concentrated, to give the title product as a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06197729B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-45ef1fa7ac7e413a9fd67f9f07bc3831 |
| Source note | uspto-grants-2001_03 |